histone H4R3 methyltransferase activity [GO_0044020]

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me.
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histone H4R3 methyltransferase activity

ID: GO_0044020

Class

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me.

Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.

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Classification

Alternative Names

Synonym Scope Reference
histone methylase activity (H4-R3 specific) exact synonym mah
histone H4R3 arginine methylase activity exact synonym
histone-arginine N-methyltransferase activity (H4-R3 specific) exact synonym
histone methyltransferase activity (H4-R3 specific) exact synonym
histone H4KR3 methylation exact synonym

References