histone H2AT120 kinase activity [GO_1990244]

Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A.

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Class
GO

histone H2AT120 kinase activity

ID: GO_1990244

Class

Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A.

Note that the residue position corresponds to the canonical human H2A2A histone (UniProtKB:Q6FI13); this residue is conserved across all eukaryotes, but corresponds to T119 in Drosophila and S121 in yeast and Tetrahymena. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.

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Classification

Alternative Names

Synonym	Scope	Reference
histone H2AS120 kinase activity	exact synonym
histone kinase activity (H2A-T120 specific)	exact synonym
histone threonine kinase activity (H2A-T120 specific)	exact synonym
histone H2A-T120 kinase activity	exact synonym

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